How to Start the Grandmapocalypse To start the Grandmapocalypse you need to unlock the Grandma upgrade One Mind. This is the very beginning stage of the Grandmapocalypse and takes a few hours to get if it is your first time playing Cookie Clicker. To get One Mind, you first need 7 types of Grandmas (see the next section).
Wrinklers are incredibly good for you in Cookie Clicker. They increase your CPS by 6x if you let ten of them pile up. Another incredibly important part of the Grandmapocalypse is Wrath Cookies. These are the red version of Golden Cookies and, unlike their golden counterparts, can have negative effects instead of positive.
The boost in CpS from purchasing the elder pledge can be a huge gift in the beginning of the end game of Cookie Clicker. Players can increase their clicking output by over 100x with enough cursors which can give a huge boost to cookie output when saving for additional Portals or the coveted Time Machine.
whatever the most expensive upgrade is you unlocked. Usually the best is your most expensive kitten, most expensive idleverse upgrade, and then most expensive multiple-of-100 cookies you have unlocked. Although I also like to keep the fortune kitten upgrade just because I don't feel like waiting for it to reappear.